专利名称：Iontophoretic delivery of cell adhesion
inhibitors
发明人：Burton H. Sage,Carl Randolph Bock,Philip G.
Green,Munir A. Hussain,Arnold J. Repta
申请号：US08/878493申请日：19970618公开号：US05961483A公开日：19991005
摘要：This invention relates to novel methods and devices for iontophoreticallyadministering therapeutic doses of cell adhesion receptor antagonists in a controlledmanner through the skin. Such antagonist compounds include but are not limited toantagonists of the IIb/IIIa and &agr;.sub.v &bgr;.sub.3 integrins and related cell surfaceadhesive protein receptors. The present invention includes iontophoretic delivery devicescomprising cell adhesion receptor antagonists. Such methods and devices are useful,alone or in combination with other therapeutic agents, for the treatment of
thromboembolic disorders, angiogenic disorders, inflammation, bone degradation, cancermetastasis, diabetic retinopathy, restenosis, macular degeneration, and other conditionsmediated by cell adhesion and/or cell migration and/or angiogenesis.
申请人：SAGE; BURTON H.,BOCK; CARL RANDOLPH,GREEN; PHILIP G.,HUSSAIN; MUNIRA.,REPTA; ARNOLD J.
代理机构：Hoffmann & Baron, LLP
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